Phylogica has big six months ahead

0.0420.004 (9.52%)View full PYC report with
  1. 18
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  2. 18
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    Yesterday PYC's Shane Stone spoke at the International Conference on Circular Proteins at Moreton Island.

    http://www.circularproteins.org/images/ICCP2015_abstracts.pdf

    Here is the abstract of the presentation:

    'Pseudo-cyclic Phylomer libraries through loop engineering of a display scaffold'

    Shane Stone* 1, 2 , Tatjana Heinrich 1, 2 , Paula Cunningham 1, 2 , Paul Watt 2, Katrin Hoffmann 2 , Richard Hopkins 2 1 Telethon Kids Institute, Australia; 2 Phylogica, Australia

    We are developing a novel way to generate genetically encoded cyclic Phylomer libraries through the loop engineering of a display scaffold. Phylomer libraries are collections of peptides that are derived from fragments of biodiverse microbial genomes and cover vast structural and sequence space. Given their genomic source, Phylomers are enriched for structure and have evolved for protein-protein interactions, making them an ideal screening resource against protein targets. Cyclisation of peptides confers appealing drug-like properties such as increased structural stability, protease resistance, increased serum stability and half-life, and extending to improved target affinities. In essence, cyclisation improves the druggability potential of a peptide and incorporating this into a screening platform could vastly improve the quality of hits. Classic peptide cyclisation requires covalent linkage between the termini or side chains of a peptide sequence, which is difficult to achieve in a genetically encoded environment. Instead we have engineered a loop of a stable scaffold to display Phylomer peptides, where the intrinsic structural stability of the scaffold constrains the termini of the Phylomer sequence in close proximity, consequently conferring pseudo-cyclic characteristics to the display loop. We have undertaken a range of proof-of-concept studies of our cyclic Phylomer display platform and present evidence validating the concept along with several potential applications.

    ..........................................................

    Cheers

    SoT

    1 like
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    I reckon, shares are toast backing this company.

    Sure the company will try to pump a few announcements in the next 6 months so

    investors in the Cap raising can get out with a profit, but really they are just passing the losses to newcomers taken in by hyped up rhetoric.

    It has a sp of 1.2 cents for good reason.

    http://asxlongtail.com/tag/pyc/

    1 like
  4. 1.7k
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    Something happening must be big news coming!!! :shock :shock :wink:

  5. 2.6k
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    Maybe. just don't get caught holding the can. :!

  6. 3.5k
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    Very confident with pyc sp reaching 5c short term, got in @1.2c

  7. 3.5k
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    Sird

    Waited 12 months to get a bag lol
    Was a decent bag, worth the wait

    2 likes
  8. 3.6k
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    a year?? lol, you have balls of patience mate..!

    2 likes
  9. 3.0k
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    Haha thats a fishing skill sird

    2 likes
  10. 3.6k
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    i might have to take up fishing, if thats the case! still learning to hold a stock
    longer then 2 months..lol
    run out of patience too quickly..

    2 likes
  11. 3.5k
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    Got in 28th jan lol

    Still holding few more oldies
    Ady prr pyc rno bly lyc

    2 likes
  12. 3.5k
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    No patience don't go fishing lol

    2 likes
  13. 3.5k
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    Pyc bagged as well, after 3.5c

    2 likes
  14. 3.6k
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    Are you saying Fishing won't work for me...lol
    GOOD because i was ready to go to K-mart and buy myself a Rod, to get started right away..haha

    1 like
  15. 3.5k
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    Lmao

    Nah mate, not saying that at all, you do have more patience than me for sure, by now all of those waitresses would have had junior kens lol

    3 likes
  16. 3.6k
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    LMAO.../

    I'm just scared to lose my prize possession if i don't have patience..!

    3 likes
  17. 3.5k
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    Lolllllllll

    Likewise

    Like wayne Bobbitt in u.s lol

    3 likes
  18. 3.5k
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    Didn't she bite it off lol

    3 likes
  19. 3.6k
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    LOL..haha

    2 likes
  20. 3.0k
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    hahaha did you see the pics of the girls at SirD's workplace Ken? LOL

    Campbeltown council has Catch a Carp programs Once a year SirD...you should have a go...LOL

    http://www.campbelltown.nsw.gov.au/RCC/CouncilandCouncillors/AnnualEvents/CatchaCarp

    2 likes
  21. 3.5k
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    No jep

    Sird hasn't shown any pics, selfish mate he is lmao

    1 like
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